Infrastructure serves a community for a long time. The decisions on infrastructure investments that are made now will have impacts over the decades and sometimes centuries to come. However, future conditions that may affect the infrastructure investment are deeply uncertain, and failure to manage these uncertainties could result in serious consequences. This new e-course describes an innovative methodology to deal with these uncertainties: Decision Making under Deep Uncertainty (DMDU), and how to use it to make robust decisions for long term investments in a changing world.